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brilanestrant

brilanestrant

Item no.	V2995-500mg
Manufacturer	InvivoChem LLC
CASRN	1365888-06-7
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2995CAS #:1365888-06-7Purity >=98% Description: Brilanestrant (formerly known as GDC-0810, ARN-810 and/or RG6046) is a novel, potent and orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in models of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer.tamoxifen-resistant breast cancer xenografts. GDC-0810 induces a distinct ERalpha conformation versus tamoxifen and other ER therapeutics, and does not exhibit tamoxifen-like ER agonism in MCF7 cells. Description: References: Elife. 2016 Jul 13; 5. pii: e15828; J Med Chem. 2015 Jun 25; 58(12):4888-904. References:
Molecular Weight (MW)	446.9
Formula	C26H20ClFN2O2
CAS No.	1365888-06-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 30 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	O=C(O)/C=C/C1=CC=C(C=C1)/C(C2=CC3=C(NN=C3)C=C2)=C(CC)\C4=CC=C(C=C4Cl)F
Synonyms	RG6046; RG-6046; RG 6046; ARN810; ARN 810; ARN-810; GDC0810; GDC 0810; GDC-0810

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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