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diclofenac-diethylamine

diclofenac-diethylamine

Item no.	V29331-25g
Manufacturer	InvivoChem LLC
CASRN	78213-16-8
Amount	25g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V29331CAS #:78213-16-8Purity >=98% Description: Diclofenac diethylamine is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with IC50 of 0.5 ug/ml and 0.5 ug/ml for COX-1 and -2 in intact cells, respectively, used to relieve pain and reduce swelling in flammation. Diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression of beta-catenin/TCF-dependent genes. Diclofenac induces the degradation of IkappaBalpha, which increases free nuclear factor kappaB (NF-kappaB) in colon cancer cells. References: FEBS Lett. 2005 Aug 15; 579(20):4213-8; Biochim Biophys Acta. 1997 Feb 15; 1318(3):385-94. Related CAS #: 15307-86-5 (free base); 15307-79-6 (sodium)

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Amount: 25g

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