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Description:Pravastatin (CS514) is a potent HMG-CoAreductase inhibitor against sterol synthesis with IC50 of 5.6 uM. It isnatural product isolated from cultures of Nocardia autotrophica.Pravastatin competitively inhibits hepatic hydroxymethyl-glutarylcoenzyme A reductase, the enzyme which catalyzes the conversion ofHMG-CoA to mevalonate, a key step in cholesterol synthesis. This agentlowers plasma cholesterol and lipoprotein levels, and modulates immuneresponses by suppressing MHC II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
References: Immunopharmacology. 1996 Aug; 34(1):51-61; Br J Clin Pharmacol. 1994 Dec; 38(6):513-9; Clin Cancer Res. 2007 Sep 15; 13(18 Pt 1):5331-40.
Related CAS: 85956-22-5 (lactone); 81093-37-0 (free acid)
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