« Back
Home /
siramesine-hcl

siramesine-hcl

Item no.	V2908-10mg
Manufacturer	InvivoChem LLC
CASRN	224177-60-0
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2908CAS #:224177-60-0Purity >=98% Description: Formerly known as Lu-28-179, siramesine is a potent and selective agonist of sigma-2 receptor agonist. Siramesine is able to trigger cancer cell death through destabilisation of mitochondria and exhibit promising anticancer activity in vivo. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost. References: Cell Death Dis. 2013 Oct 3; 4:e818. Related CAS#: 147817-50-3 (free base); 163630-79-3 (fumarate)
Molecular Weight (MW)	491.05
Formula	C30H32ClFN2O
CAS No.	224177-60-0 (HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10 mM
	Water: < 1 mg/mL
	Ethanol:
SMILES Code	FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=CC=CC=C45)C6=C2C=CC=C6)C=C1.[H]Cl
Synonyms	Lu-28-179 HCl; Lu 28-179; Lu28-179; Lu-28179; Lu 28179; Lu28179; Siramesine HCl; Siramesine hydrochloride;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 14 days

Compare

Add to wishlist

Recommend by mail