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Description: Trapazamine (also known as TP, SR-4233; SR259075; Win59075; SR4233) is an experimental adjuvant drug and a DNA-damaging agent that has the potential for the treatment of cervical carcinoma, head and neck cancer. Tirapazamine could downregulate HIF-1alpha expression by decreasing HIF-1alpha protein synthesis when activated to its toxic form preferentially in the hypoxic areas of solid tumors. When combined with chemotherapeutic drugs such as Doxorubicin (DOX) and SN-38 (the active metabolite of irinotecan), trapazamine dramatically inhibited the accumulation of HIF-1alpha protein, decreased the HIF-1alpha transcriptional activation, and impaired the phosphorylation of proteins involved in the homologous recombination repair pathway, ultimately resulting in the synergism of these two drugs.
References: Oxid Med Cell Longev. 2012; 2012:890826; Mol Cancer Ther. 2014 Mar; 13(3):630-42.
SR 4233; SR-4233; SR4233; SR259075; SR-259075; SR 259075; WIN 59075; WIN-59075; WIN59075; NSC130181; NSC-130181; NSC 130181; Tirazone; TP; Tirapazamine;
Chemical Name: 3-aminobenzo[e][1, 2, 4]triazine 1, 4-dioxide
Exact Mass: 178.04908
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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