t-5224

Item no.	V2895-50mg
Manufacturer	InvivoChem LLC
CASRN	530141-72-1
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2895CAS #:530141-72-1Purity >=98% Description: T-5224 is a novel and selective inhibitor of c-Fos/activator protein-1 (AP-1) which is a transcriptional factor that regulates the expression of various genes associated with tumor invasion and migration. T-5224 has potential use in cancer and rheumatoid arthritis therapy. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T-5224 has been investigated in phase II human clinical trials. T-5224 (0-80 uM) significantly inhibits the invasion, migration, and MMP activity of HSC-3-M3 cells in a dose-dependent manner. T-5224 inhibited the invasion and migration of HNSCC cells in vitro, and prevented lymph node metastasis in head and neck cancer in an animal model. References: Cancer Sci. 2016 May; 107(5):666-73; Drug Metab Dispos. 2011 May; 39(5):803-13.
Molecular Weight (MW)	517.53
Formula	C29H27NO8
CAS No.	530141-72-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 31 mg/mL
	Water: NA
	Ethanol: NA
Chemical Name	3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxybenzo[d]isoxazol-6-yl)methoxy)phenyl)propanoic acid
SMILES Code	O=C(O)CCC1=CC(C(C2=CC=C(OC3CCCC3)C=C2O)=O)=CC=C1OCC4=CC5=C(C=C4)C(O)=NO5
Synonyms	T-5224, T 5224, T5224,

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