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exendin-4-acetate

exendin-4-acetate

Item no.	V28800-50mg
Manufacturer	InvivoChem LLC
CASRN	914454-01-6
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V28800CAS #:914454-01-6Purity >=98% Description: Exenatide acetate (Exendin-4 Acetate), a bioactivepeptide composed of 39 amino acids, is antidiabetic medication acting asa long-acting glucagon-like peptide-1 receptor agonist with an IC50 of3.22 nM. As a synthetic form of endogenous glucagon-likepeptide-1, Exenatide stimulates insulin secretion, inhibits glucagonrelease, decreases appetite, and slows gastric emptying. As such, it isused as add-on therapy for diabetes mellitus. References: 1. The importance of the nine-amino acid C-terminal sequence ofexendin-4 for binding to the GLP-1 receptor and for biologicalactivity. Regul Pept. 2003 Jul 15; 114(2-3):153-8. 2. Exenatide exerts direct protective effects on endothelialcells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependentmanner. Am J Physiol Endocrinol Metab. 2016 Jun 1; 310(11):E947-57. 3. Antidiabetic exendin-4 activates apoptotic pathway andinhibits growth of breast cancer cells. Tumour Biol. 2016Feb; 37(2):2647-53. Related CAS #:141758-74-9 (free base) 141732-76-5 or 914454-01-6 (acetate) 914454-01-6

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Amount: 50mg

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