ro-61-8048

Description: Ro 61-8048 is a novel, high-affinity, oral, potent and selective kynurenine hydroxylase inhibitor with IC50 of 37 nM. It can improve dystonia in a genetic model of paroxysmal dyskinesia and has the potential to be used for the treatment of dyskinesias. In addition, Ro 61-8048 may be useful to reduce neuronal loss in brain ischemia. Upon oral administration, Ro 61-8048 blocked rat and gerbil kynurenine 3-hydroxylase with ED50's in the 3-5 mumol/kg range in gerbil brain. In a microdialysis experiment in rats, Ro 61-8048 dose dependently increased kynurenic acid concentration in the extracellular hippocampal fluid. A dose of 100 mumol/kg po led to a 7.5-fold increase in kynurenic acid outflow.

References: J Cereb Blood Flow Metab. 1999 Jul; 19(7):771-7; J Med Chem. 1997 Dec 19; 40(26):4378-85.