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Description: Guadecitabine sodium (SGI-110 sodium; S-110 sodium), a dinucleotide consisting of 5-Aza-CdR followed by a deoxyguanosine, is a novel and potent DNA methyltransferases (DNMT) inhibitor with the potential to be used for treating acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
References:
1. Yoo CB, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1; 67(13):6400-8.
2. ChuangJC, et al. S-110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, isan effective DNA methylation inhibitor in vivo and can reduce tumorgrowth. Mol Cancer Ther. 2010 May; 9(5):1443-50.
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