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caccinh-a01

caccinh-a01

Item no.	V2866-250mg
Manufacturer	InvivoChem LLC
CASRN	407587-33-1
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2866CAS #:407587-33-1Purity >=98% Description: CaCCinh-A01 (also known as TMEM16 Blocker I) is an inhibitor of TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 uM, respectively. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). CaCCs are widely expressed in mammalian tissues, including intestinal epithelia, where they facilitate fluid secretion. CaCCinh-A01 is a non-selective inhibitor of CaCCs that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 uM). As a TMEM16A/CaCC inhibitor, CaCCinh-A01 is a potential development candidate for drug therapy of hypertension, pain, diarrhea, and excessive mucus production. References: J Biol Chem. 2011 Jan 21; 286(3):2365-74.
Molecular Weight (MW)	347.43
Formula	C18H21NO4S
CAS No.	407587-33-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: < 1 mg/mL
	Ethanol:
SMILES Code	O=C(C1=C(NC(C2=CC=CO2)=O)SC3=C1CCC(C(C)(C)C)C3)O
Synonyms	CaCC(inh)-A01; CaCCinh-A01; TMEM16 Blocker I.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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