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Description: XCT790 is a selective ERRalpha antagonist/inverse agonist (IC50 = ca.400 nM). XCT790 exhibits no antagonist activity at ERRgamma or ERalpha at concentrations below 10 uM. It interferes with PPARgamma coactivator-1alpha (PGC-1alpha)/ERRalpha-dependent signaling.
References: Lu YH, Li QY, Chen L, Shi XJ. XCT790 inhibits rat vascular smooth muscle cells proliferation through down-regulating the expression of estrogen-related receptor alpha. Yao Xue Xue Bao. 2014 Feb; 49(2):190-7. Chinese. PubMed PMID: 24761608.
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