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Description: Valemetostat, formerly known as DS-3201 or DS-3201b, is an investigational EZH1/2 dual inhibitor with anticancer activity, it targetsepigenetic regulation by inhibiting the EZH1, as well as EZH2 enzymes, which regulate gene expression by acting through histone methylation. Valemetostat is being evaluated in Phase I clinical development for severaltypes of NHLs, including ATL, peripheral T-cell lymphoma (PTCL) andB-cell lymphomas. Patients are currently being enrolled for the trial inthe US and Japan.
References: https://www.clinicaltrialsarena.com/news/daiichi-sankyo-valemetostat-atl/
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