InvivoChem Cat #:V27837CAS #:1956366-10-1Purity >=98%Description: Ulixertinib (formerly also known as BVD-523 and VRT752271) is a novel, potent, orally bioactive, highly selective, ATP-competitive and reversible ERK1/ERK2 inhibitor with IC50 of< 0.3 nM for ERK2. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways.
References: J Med Chem. 2015 Jun 11; 58(11):4790-801.
Related CAS #: 1956366-10-1 (HCl) 869886-67-9 (free base) 1975172-95-2 (HCl hydrate)