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hjc0152-hydrochloride

hjc0152-hydrochloride

Item no.	V2741-250mg
Manufacturer	InvivoChem LLC
CASRN	1420290-99-8
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2741CAS #:1420290-99-8Purity >=98% Description: HJC0152 hydrochloride is a novel, orally bioavailable and potent inhibitor of the signal transducers and activators of transcription 3 (STAT3). It has potential application for treating human head and neck squamous cell carcinoma (HNSCC). HJC0152 has been demonstrated to significantly suppress MDA-MB-231 xenograft tumor growth in vivo (i.p. & p.o.), indicating its great potential as efficacious and orally bioavailable therapeutics for human cancers. HJC0152 was designed and developed based on niclosamide which has been identified to potently inhibit the activation, nuclear translocation, and transactivation of STAT3 but with pharmacokinetics such as poor aqueous solubility and bioavailability of niclosamide. HJC0152 has improved pharmacokinetic profiles. Description: References: ACS Med Chem Lett. 2013 Feb 14; 4(2):180-185. References:
Molecular Weight (MW)	406.64
Formula	C15H14Cl3N3O4
CAS No.	1420290-99-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 5 mg/mL (under ultrasonic condition)
	Water: N/A
	Ethanol: N/A
Chemical Name	2-(2-Amino-ethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Hydrochloride
Synonyms	HJC0152; HJC 0152 HCl; HJC-0152 hydrochloric acid
SMILES Code	O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2OCCN.[H]Cl

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250mg

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Delivery expected until 9/6/2024

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