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parsaclisib-hcl

parsaclisib-hcl

Item no.	V27114-25mg
Manufacturer	InvivoChem LLC
CASRN	1995889-48-9
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V27114CAS #:1995889-48-9Purity >=98% Description:Parsaclisib HCl, formerly known as INCB050465, is a novel and potent PI3Kdeltainhibitor which synergizes with PIM protein kinase inhibition to causetumor regression in a model of DLBCL. INCB050465 inhibits PI3Kdelta with an IC₅₀of 1 nM at 1 mM ATP, and shows appr 20, 000-fold selectivity for PI3Kalpha, PI3Kbeta, PI3Kgamma and 57 other kinases. INCB050465 displays potent activitywith IC50 ranging from 0.2 to 2 nM. In addition, INCB050465 blocks theproliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10nM) and can slow tumor growth in the Pfeiffer model of DLBCL in vivo. References: Abstract2671: INCB050465, a novel PI3Kdelta inhibitor, synergizes with PIM proteinkinase inhibition to cause tumor regression in a model of DLBCL. CancerResearch. 2015, Aug. 75(15). Related CAS #: 1995889-48-9 (HCl) 1426698-88-5 (free base) Description:Parsaclisib HCl, formerly known as INCB050465, is a novel and potent PI3Kdeltainhibitor which synergizes with PIM protein kinase inhibition to causetumor regression in a model of DLBCL. INCB050465 inhibits PI3Kdelta with an IC₅₀of 1 nM at 1 mM ATP, and shows appr 20, 000-fold selectivity for PI3Kalpha, PI3Kbeta, PI3Kgamma and 57 other kinases. INCB050465 displays potent activitywith IC50 ranging from 0.2 to 2 nM. In addition, INCB050465 blocks theproliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10nM) and can slow tumor growth in the Pfeiffer model of DLBCL in vivo. References: Abstract2671: INCB050465, a novel PI3Kdelta inhibitor, synergizes with PIM proteinkinase inhibition to cause tumor regression in a model of DLBCL. CancerResearch. 2015, Aug. 75(15). Related CAS #: 1995889-48-9 (HCl) 1426698-88-5 (free base)

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Amount: 25mg

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Delivery expected until 9/6/2024

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