InvivoChem Cat #:V26632CAS #:41332-24-5Purity >=98%Description: NP-118809 is a N-type calcium channel blocker. NP-118809 exhibits both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain. NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel.
References: Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, SnutchTP. Structure-activity relationships of diphenylpiperazine N-type calcium channelinhibitors. Bioorg Med Chem Lett. 2010 Feb 15; 20(4):1378-83. doi:10.1016/j.bmcl.2010.01.008. Epub 2010 Jan 7. PubMed PMID: 20117000.