prima-1

Description: PRIMA-1 also known as Prima-1; chemcial name, 2, 2-Bis(hydroxymethyl)-3-quinuclidinone, a novel and potent small molecule compound which is the active form of APR-246 (also known as PRIMA-1MET), is a mutant p53 reactivator which induces apoptosis and inhibits growth of human tumors. It has the potential to treat various human tumor types that are mutant p53-dependent. PRIMA-1 rescues the tumor-suppressing function of mutant p53 proteins and shows anti-tumor activity in vivo. P53 severs as a crucial tumor suppressor and mutant p53 is expressed at high levels in many tumors. PRIMA-1 is considered as a lead compound for the development of anticancer drugs targeting mutant p53.

References: Invest New Drugs. 2014 Oct; 32(5):783-94; Cancer Cell. 2009 May 5; 15(5):376-88; Nat Med. 2002 Mar; 8(3):282-8.

Related CAS#:5291-32-7 (PRIMA-1MET; APR-246)