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Description: Etomoxir sodium salt, the sodium salt form of etomoxir, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. It inhibits beta-oxidation in mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells. Etomoxir has also been identified as a direct agonist of PPARalpha. Etomoxir is a compound that binds irreversibly to the catalytic site of CPT-1 inhibiting its activity, but also upregulates fatty acid oxidation enzymes.
References: Herz. 2002 Nov; 27(7):621-36; Sci Rep. 2011; 1:79; Neuro Oncol. 2017 Jan; 19(1):43-54.
Related CAS #: 828934-41-4 (sodium) 124083-20-1 82258-36-4 (racemate)
Chemical Name: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid monosodium salt
SMILES Code: O=C([C]1(CCCCCCOC2=CC=C(Cl)C=C2)OC1)[O-].[Na+]
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