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tariquidar-methanesulfonate-hydrate

tariquidar-methanesulfonate-hydrate

Item no.	V2575-250mg
Manufacturer	InvivoChem LLC
CASRN	625375-83-9
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2575CAS #:625375-83-9 Purity >=98% Description: Tariquidar methanesulfonate hydrate (formerly also known as XR9576) is a novel potent and selective noncompetitive inhibitor of P-glycoprotein (P-gp) with Kd of 5.1 nM in CHrB30 cell line, it reverses drug resistance in MDR cell Lines. Tariquidar is currently undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. References: Br J Pharmacol. 1999 Sep; 128(2):403-11; Cancer Res. 2001 Jan 15; 61(2):749-58. Related CAS#: 206873-63-4 (free base); 625375-84-0 (dimesylate); 625375-83-9 (dimesylate hydrate). : 206873-63-4 (free base); 625375-84-0 (dimesylate); 625375-83-9 (dimesylate hydrate).206873-63-4 (free base);
Molecular Weight (MW)	892.99
Formula	C40H52N4O12S2
CAS No.	625375-83-9 (dimesylate hydrate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 296 mg/mL
	Water: < 8.9 mg/mL
	Ethanol: < 8.9 mg/mL
Solubility (In vivo)	O=C(C1=CC2=CC=CC=C2N=C1)NC3=CC(OC)=C(OC)C=C3C(NC4=CC=C(CCN5CC6=C(C=C(OC)C(OC)=C6)CC5)C=C4)=O.CS(=O)(O)=O.CS(=O)(O)=O.O.O.O
Synonyms	XR9576 methanesulfonate; XR 9576; XR-9576 methanesulfonate; D06008 methanesulfonate; D 06008; D-06008; Tariquidar methanesulfonate

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Amount: 250mg

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Delivery expected until 9/6/2024

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