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Description: I-191 is a potent antagonist of protease-activated receptor 2 (PAR2). I-191 inhibits multiple signaling functions in human cancer cells.
References: Jiang Y, Yau MK, Lim J, Wu KC, Xu W, Suen JY, Fairlie DP. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb; 364(2):246-257. doi: 10.1124/jpet.117.245027. Epub 2017 Dec 20. PubMed PMID: 29263243.
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