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losartan

losartan

Item no.	V24404-200g
Manufacturer	InvivoChem LLC
CASRN	114798-26-4
Amount	200g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V24404CAS #:114798-26-4Purity >=98% Description: Losartan (DuP-753) is a potent, selective, and non-peptide angiotensin II receptor antagonist, it competes with angiotensin II for binding to AT1 receptors with IC50 of 20 nM. Losartan inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). It is used as an orally active antihypertensive agent. Losartan (180 mg/d) causes significant increases in plasma angiotensin II and angiotensin-(1-7) in monkeys with diet-induced hypercholesterolemia. References: Circulation. 2001 Feb 13; 103(6):904-12; Circulation. 2000 Apr 4; 101(13):1586-93. Related CAS #: 124750-99-8 (Ka+) 114798-26-4 (free)

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