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Description: Maxacalcitol (22-Oxacalcitriol) is a novel calcitriol analog without hypercalcemic side effects. It is an agonist of vitamin D3/2 receptor (VDR) and can effectively block PTH synthesis. Maxacalcitol (OCT) induces hCAP-18/LL-37 production in human orally bioavailable epithelial cells. Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.
References:
1. Barroga, et al. Inhibitory effects of 22-oxa-calcitriol and all-trans retinoicacid on the growth of a canine osteosarcoma derived cell-line in vivoand its pulmonary metastasis in vivo. Res.Vet.Sci. (2000)68 79.
2. Monier-Faugere, et al. 22-Oxacalcitriol suppresses secondary hyperparathyroidismwithout inducing low bone turnover in dogs with renal failure. KidneyInt. (1999)55 821.
3. InoueK, et al. Maxacalcitol ameliorates tubulointerstitial fibrosis inobstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.Lab Invest.2012 Aug 27.
4. Karashima T, et al. Successful Treatment of Bowen's Disease with Topical Maxacalcitol.Acta Derm Venereol. 2012 Jan 26.
5. Effects of maxacalcitol ointment on skin lesions in patients with psoriasis receiving treatment with adalimumab. J Dermatol. 2016 Nov; 43(11):1354-1357. doi: 10.1111/1346-8138.13515. Epub 2016 Jul 23. PubMed PMID: 27450634.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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