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k-ras-inhibitor-6

k-ras-inhibitor-6

Item no.	V2420-250mg
Manufacturer	InvivoChem LLC
CASRN	2060530-16-5
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2420CAS #:2060530-16-5Purity >=98% Description: K-Ras (G12C) inhibitor 6 is a novel, potent, allosteric/irreversible, cysteine-reactive small molecule and selective inhibitor of oncogenic K-Ras(G12C) that causes 100% modification of the protein when used at 10 uM for 24 hours in vitro. It binds to the G12C mutantion of GTPase K-Ras irreversibly but does not bind the wild-type K-Ras with the relative potency value of 4.2. The binding pocket of K-Ras for K-Ras (G12C) inhibitor 6 is a new allosteric pocket, S-IIP. Binding of this pocket results in a change of the relative nucleotide affinity of Ras to favour GDP over GTP, leading to an accumulation of inactive Ras. References: Nature. 2013 Nov 28; 503(7477):548-51.
Molecular Weight (MW)	405.34
Formula	C17H22Cl2N2O3S
CAS No.	2060530-16-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 81 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 30 mg/mL (74.0 mM)
Other info	Chemical Name: N-(1-(2-(2, 4-dichlorophenoxy)acetyl)piperidin-4-yl)-4-mercaptobutanamide InChi Key: ZPXCEHMKUTXHRZ-UHFFFAOYSA-N InChi Code: InChI=1S/C17H22Cl2N2O3S/c18-12-3-4-15(14(19)10-12)24-11-17(23)21-7-5-13(6-8-21)20-16(22)2-1-9-25/h3-4, 10, 13, 25H, 1-2, 5-9, 11H2, (H, 20, 22) SMILES Code: ClC1=CC=C(OCC(N2CCC(NC(CCCS)=O)CC2)=O)C(Cl)=C1
Synonyms	K-Ras(G12C) Inhibitor-6

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Amount: 250mg

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Delivery expected until 10/4/2024

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