medi-9197

Description: Telratolimod (MEDI9197, MEDI-9197, 3M-052) is a novel and potent agonist of toll-like receptor 7/8 (TLR-7/8) with the potential for the treatment of solid tumors. Telratolimod is an IRM bearing a C18 lipid moiety and designed for slow dissemination from the site of application. MEDI-9197 drives a strong Th1 response to hemagglutinin and serum neutralization of viable H1N1 A/Puerto Rico/8/34 virus in the absence of circulating TNFalpha or the induction of Th1 cytokines.

References: Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13; 2:12; Vaccine adjuvant activity of 3M-052: an imidazoquinoline designed for local activity without systemic cytokine induction. Vaccine. 2011 Jul 26; 29(33):5434-42.