iox4

Item no.	V22628-5mg
Manufacturer	InvivoChem LLC
CASRN	1154097-71-8
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1154097-71-8
Available
Description	InvivoChem Cat #:V22628CAS #:1154097-71-8Purity >=98% Description: OX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM). IOX4 induces HIFalpha in cells and in wildtype mice with marked induction in the brain tissue, revealing that it is useful for studies aimed at validating the upregulation of HIF for treatment of cerebral diseases including stroke. References: Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gomez-Perez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, KawamuraA, Pugh CW, Ratcliffe PJ, Schofield CJ. Potent and Selective Triazole-BasedInhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity inthe Murine Brain. PLoS One. 2015 Jul 6; 10(7):e0132004. doi:10.1371/journal.pone.0132004. eCollection 2015. PubMed PMID: 26147748; PubMedCentral PMCID: PMC4492579.

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