vbit4

Item no.	V2258-50mg
Manufacturer	InvivoChem LLC
CASRN	2086257-77-2
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2258CAS #:2086257-77-2Purity >=98% Description: VBIT-4 is a novel and potent inhibitor of VDAC1 (voltage-dependent anion channel 1), which is the outer mitochondrial membrane protein and a convergence point for a variety of cell survival anddeath signals, including apoptosis. VBIT-4 offers a therapeutic strategy for treating different diseasesassociated with enhanced apoptosis and point to VDAC1 as a promisingtarget for therapeutic intervention. References: 1) Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25; 291(48):24986-25003. doi: 10.1074/jbc.M116.744284. Epub 2016 Oct 13.PMID: 27738100; doi: 10.1074/jbc.M116.744284. Epub 2016 Oct 13.PMID: 2773810027738100 2) Science. 2019 Dec 20; 366(6472):1531-1536. doi: 10.1126/science.aav4011. Epub 2019 Dec 19.PMID: 31857488 Science. 2019 Dec 20; 366(6472):1531-1536. doi: 10.1126/science.aav4011. Epub 2019 Dec 19.PMID: 3185748831857488 3) Sci Rep. 2020 Dec 16; 10(1):22101. doi: 10.1038/s41598-020-79056-w. PMID: 33328613 3) Sci Rep. 2020 Dec 16; 10(1):22101. doi: 10.1038/s41598-020-79056-w. PMID: 33328613 PMID: 3332861333328613 Related CAS #: 2086268-69-9 (R-isoemr); 2086269-51-2 (S-isomer); 2086257-77-2 (racemate); Related CAS #: 2086268-69-9 (R-isoemr); 2086269-51-2 (S-isomer); 2086257-77-2 (racemate);

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