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Description: VBIT-4 is a novel and potent inhibitor of VDAC1 (voltage-dependent anion channel 1), which is the outer mitochondrial membrane protein and a convergence point for a variety of cell survival anddeath signals, including apoptosis. VBIT-4 offers a therapeutic strategy for treating different diseasesassociated with enhanced apoptosis and point to VDAC1 as a promisingtarget for therapeutic intervention.
References:
1) Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25; 291(48):24986-25003. doi: 10.1074/jbc.M116.744284. Epub 2016 Oct 13.PMID: 27738100;
2) Science. 2019 Dec 20; 366(6472):1531-1536. doi: 10.1126/science.aav4011. Epub 2019 Dec 19.PMID: 31857488
3) Sci Rep. 2020 Dec 16; 10(1):22101. doi: 10.1038/s41598-020-79056-w. PMID: 33328613
Related CAS #: 2086268-69-9 (R-isoemr); 2086269-51-2 (S-isomer); 2086257-77-2 (racemate);
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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