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h3b-6545

h3b-6545

Item no.	V22038-5mg
Manufacturer	InvivoChem LLC
CASRN	2052130-80-8
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V22038CAS #:2052130-80-8Purity >=98% Description: H3B-6545 is a novel, potent, orally bioavailable and selective small molecule modulator of wild-type and mutant Estrogen Receptor (ERalpha). Preclinical data indicates H3B-6545 inhibits the growth of cell line and patient-derived xenograft models of wild-type and mutant ERalpha with improved activity over standard-of-care therapies. References: 1. PeterG. Smith, et al. Abstract DDT01-04: Discovery and development ofH3B-6545: A novel, oral, selective estrogen receptor covalent antagonist(SERCA) for the treatment of breast cancer.AACR Annual Meeting 2017; April 1-5. 2. Manav Korpal, et al. Development of a First-in-Class Oral Selective ER Covalent Antagonist (SERCA) for the Treatment of ERalpha^WT and ERalpha^MUT Breast Cancer. 3. Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novelselective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2018 Nov1. doi: 10.1007/s00280-018-3716-3.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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