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Description: SC-26196 is a novel, potent and orally bioactive D6D (Delta6 desaturase) inhibitor with IC50 of 0.2 uM in a rat liver microsomal assay. It completely blocks the conversion of linoleic acid to arachidonic acid (AA). SC-26196 inhibited the desaturation of 2 microM 1-14C 18:2n-6 by 87-95% in cultured human skin fibroblasts, coronary artery smooth muscle cells, and astrocytes. By contrast, SC-26196 did not affect the conversion of 1-14C20:3n-6 to 20:4 in the fibroblasts, demonstrating that it is selective for delta6-desaturase.
References:
1. ObukowiczMG, et al. Novel, selective delta6 or delta5 fatty acid desaturaseinhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther.1998 Oct; 287(1):157-66.
2. Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving delta8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5; 9:432.
3. Hargrave-BarnesKM, et al. Conjugated linoleic acid-induced fat loss dependence onDelta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008Oct; 16(10):2245-52.
4. ZhangL, et al. A multiplexed cell assay in HepG2 cells for theidentification of delta-5, delta-6, and delta-9desaturase and elongaseinhibitors. J Biomol Screen. 2010 Feb; 15(2):169-76.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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