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sc26196

sc26196

Item no.	V2164-25mg
Manufacturer	InvivoChem LLC
CASRN	218136-59-5
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2164CAS #:218136-59-5Purity >=98% Description: SC-26196 is a novel, potent and orally bioactive D6D (Delta6 desaturase) inhibitor with IC50 of 0.2 uM in a rat liver microsomal assay. It completely blocks the conversion of linoleic acid to arachidonic acid (AA). SC-26196 inhibited the desaturation of 2 microM 1-14C 18:2n-6 by 87-95% in cultured human skin fibroblasts, coronary artery smooth muscle cells, and astrocytes. By contrast, SC-26196 did not affect the conversion of 1-14C20:3n-6 to 20:4 in the fibroblasts, demonstrating that it is selective for delta6-desaturase. References: 1. ObukowiczMG, et al. Novel, selective delta6 or delta5 fatty acid desaturaseinhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther.1998 Oct; 287(1):157-66. 2. Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving delta8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5; 9:432. 3. Hargrave-BarnesKM, et al. Conjugated linoleic acid-induced fat loss dependence onDelta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008Oct; 16(10):2245-52. 4. ZhangL, et al. A multiplexed cell assay in HepG2 cells for theidentification of delta-5, delta-6, and delta-9desaturase and elongaseinhibitors. J Biomol Screen. 2010 Feb; 15(2):169-76.

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