gne684

Item no.	V2133-10mg
Manufacturer	InvivoChem LLC
CASRN	N/A
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2133CAS #:N/APurity >=98% Description: GNE684 is a novel and potent inhibitor of receptor interacting protein 1 (RIP1), it inhibits human RIP1 potently over than mouse and rat with IC50s of 21 nM, 189 nM and 691 nM, respectively. The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases. References: Cell Death Differ. 2019 May 17.
	Molecular Weight: 432.48 Formula: C??H??N?O? SMILES: COC1=NC=C(N(C)C([CH](NC(C2=NN([CH]C3=CC=CC=C3)CC4)C4=N2)=O)CC5)=O)C5=C1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	GNE-684; GNE 684; GNE684

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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