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Description: GNE684 is a novel and potent inhibitor of receptor interacting protein 1 (RIP1), it inhibits human RIP1 potently over than mouse and rat with IC50s of 21 nM, 189 nM and 691 nM, respectively. The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases.
References: Cell Death Differ. 2019 May 17.
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