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Description: Suplatast Tosilate (also known as IPD-1151T) is a novel capsular anti-asthmatic and anti-allergic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 uM. Suplatast tosilate has an inhibitory effect on antibody production in isolated mouse splenic and human peripheral blood B cells with IC50 ?100 nM. Suplatast tosilate inhibits mouse and human cytokine production, IFN-gamma, IL-2, IL-4, IL-5 and IL-10 with an IC50 ?100 nM. The induction of Cryj1-dependent IgE synthesis mediated by SN-4 is suppressed in a concentration-dependent manner by Suplatast tosilate (1 and 10 ug/ml) in autologous B cells.
References: J Pharmacol Exp Ther. 2005 Jul; 314(1):293-301; Jpn J Pharmacol. 1993 Jan; 61(1):31-9; Int Arch Allergy Immunol. 2000 Feb; 121(2):116-22.
Related CAS #: 94055-75-1 (free base); 94055-76-2 (tosylate)
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