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Description: Palosuran (ACT-058362) is a potent and orally bioavailable Urotensin-II receptor antagonist (IC50=3.6 nM)with potential use in pulmonary arterial hypertension.
References:
1. Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System. J Pharmacol Exp Ther. 2004 Oct; 311(1):204-12.
2. The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats. J Pharmacol Exp Ther. 2006 Mar; 316(3):1115-21.
3. Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension. Inflammation. 2014 Aug; 37(4):1280-8.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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