drospirenone

Description: Drospirenone is a synthetic progestogen exhibiting antiandrogenic and antimineralocorticoid activity. This drug is used in orally bioavailable contraceptives. Drospirenone binds to the progesterone receptor, the resulting complex becomes activated and binds to specific sites on DNA. This results in a suppression of LH activity and an inhibition of ovulation as well as an alteration in the cervical mucus and endometrium. This leads to an increased difficulty of sperm entry into the uterus and implantation.

References: Borgo MV, Claudio ER, Silva FB, Romero WG, Gouvea SA, Moyses MR, Santos RL, Almeida SA, Podratz PL, Graceli JB, Abreu GR. Hormonal therapy with estradiol anddrospirenone improves endothelium-dependent vasodilation in the coronary bed ofovariectomized spontaneously hypertensive rats. Braz J Med Biol Res. 2016; 49(1).pii: S0100-879X2016000100601. doi: 10.1590/1414-431X20154655. Epub 2016 Nov 17.PubMed PMID: 26577845; PubMed Central PMCID: PMC4678653.