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Description: Dextropimaric acid (Pimaric acid), a resin acid isolated from A. cordata and various pines, is a shaker channel opener. It acts by inhibiting of TNF-alpha-induced MMP-9 production and HASMC migration via down-regulated NF-kappaB and AP-1. It reduces mRNA expression, protein levels, and promoter activity of matrixmetalloproteinase-9 (MMP-9) in TNF-alpha-stimulated human aortic smoothmuscle cells (HASMCs).
References: HARRIS GC, SANDERSON TF. Resin acids; the position of the ring double bond in dextropimaric acid and the structure of isodextropimaric acid. J Am Chem Soc. 1948 Jun; 70(6):2081-5. PubMed PMID: 18863802.
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