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atglistatin

atglistatin

Item no.	V1958-5mg
Manufacturer	InvivoChem LLC
CASRN	1469924-27-3
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1469924-27-3
Available
Description	InvivoChem Cat #:V1958CAS #:1469924-27-3 Purity >=98% Description: Atglistatin is a highly potent and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 uM, it showed high selectivity over other key metabolic lipases. In lysates from E. coli overexpressing ATGL, atglistatin inhibited ATGL activity with IC50 value of 0.7 uM. Atglistatin at concentrations up to 50 uM had no cytotoxicity. Also, atglistatin inhibited ATGL with Ki value of 355 nM in a competitive way. In white adipose tissue (WAT) lysates of wild-type mice, atglistatin inhibited triacylglycerol (TG) hydrolase activity by 78%. The combination of Atglistatin and the HSL inhibitor Hi 76-007917 inhibited TG hydrolase activity by 95%. References: Nat Chem Biol. 2013 Dec; 9(12):785-7.
Molecular Weight (MW)	283.37
Formula	C17H21N3O
CAS No.	1469924-27-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 57 mg/mL (201.2 mM)
	Water: < 1 mg/mL
	Ethanol: 4 mg/mL (14.1 mM)
Other info	Chemical Name: 3-(4'-(dimethylamino)-[1, 1'-biphenyl]-3-yl)-1, 1-dimethylurea InChi Key: AWOPBSAJHCUSAS-UHFFFAOYSA-N InChi Code: InChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H, 1-4H3, (H, 18, 21) SMILES Code: CN(C1=CC=C(C=C1)C2=CC(NC(N(C)C)=O)=CC=C2)C
Synonyms	Atglistatin

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