4mu8c

Item no.	V1952-5mg
Manufacturer	InvivoChem LLC
CASRN	14003-96-4
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	14003-96-4
Available
Description	InvivoChem Cat #:V1952CAS #:14003-96-4 Purity >=98% Description: 4u8C (also known as IRE1 Inhibitor III) is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 NM. 4u8C blocks substrate(RIDD) access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation. IRE1 inhibition subsequently induces ER stress without measureable acute toxicity. 4u8C, as an IRE1 inhibitor, blocks IL-4, IL-5, and IL-13 production from CD4+ T cells. References: Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):E869-78; J Biol Chem. 2013 Nov 15; 288(46):33272-82.
Molecular Weight (MW)	204.18
Formula	C11H8O4
CAS No.	14003-96-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 19 mg/mL (93.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde InChi Key: RTHHSXOVIJWFQP-UHFFFAOYSA-N InChi Code: InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5, 13H, 1H3 SMILES Code: O=CC1=C(O2)C(C(C)=CC2=O)=CC=C1O
Synonyms	4u8C; IRE1 Inhibitor III

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 21 days

Compare

Add to wishlist

Recommend by mail