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Description: RI-1 (also known as RAD51 inhibitor 1) is an irreversible small molecule inhibitor of RAD51 with IC50 ranging from 5 to 30 uM. RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 uM range. RI-1 decreases the rejoining of gamma-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation.
References: Nucleic Acids Res. 2012 Aug; 40(15):7347-57; PLoS One. 2013 Jul 11; 8(7):e69061.
Chemical Name: 3-chloro-1-(3, 4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2, 5-dione
InChi Key: MWSUIZKGNWELRF-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2, 7H, 3-6H2
SMILES Code: O=C(C(Cl)=C1N2CCOCC2)N(C3=CC=C(Cl)C(Cl)=C3)C1=O
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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