ri-1

Item no.	V1951-100mg
Manufacturer	InvivoChem LLC
CASRN	415713-60-9
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1951CAS #:415713-60-9 Purity >=98% Description: RI-1 (also known as RAD51 inhibitor 1) is an irreversible small molecule inhibitor of RAD51 with IC50 ranging from 5 to 30 uM. RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 uM range. RI-1 decreases the rejoining of gamma-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. References: Nucleic Acids Res. 2012 Aug; 40(15):7347-57; PLoS One. 2013 Jul 11; 8(7):e69061.
Molecular Weight (MW)	361.61
Formula	C14H11Cl3N2O3
CAS No.	415713-60-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 50 mg/mL (138.3 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 3-chloro-1-(3, 4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2, 5-dione InChi Key: MWSUIZKGNWELRF-UHFFFAOYSA-N InChi Code: InChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2, 7H, 3-6H2 SMILES Code: O=C(C(Cl)=C1N2CCOCC2)N(C3=CC=C(Cl)C(Cl)=C3)C1=O
Synonyms	RAD51 inhibitor 1; RI-1; RI1; RI 1

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Amount: 100mg

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