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azd7545

azd7545

Item no.	V1942-100mg
Manufacturer	InvivoChem LLC
CASRN	252017-04-2
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1942CAS #:252017-04-2 Purity >=98% Description: AZD7545 is a novel, potent, selective small-molecule inhibitor of PDHK (pyruvate dehydrogenase kinase 2) with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. Besides that, AZD7545 increases PDH activity with EC50 value of 5.2nM when using recombinant human PDHK2. In vivo studies show that administration of AZD7545 significantly activates PDH activity in liver and partially activates PDH activity in skeletal muscle and heart. In Zucker (fa/fa) rats, AZD7545 at dose of 10 mg/kg increases muscle PDH from 61% to 97% active and liver PDH from 33.5% to 72.8%. References: Biochem Soc Trans. 2003 Dec; 31(Pt 6):1165-7; Biochemistry. 2007 Jul 24; 46(29):8592-602.
Molecular Weight (MW)	478.87
Formula	C19H18ClF3N2O5S
CAS No.	252017-04-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 95 mg/mL (198.4 mM)
	Water: < 1 mg/mL
	Ethanol: 95 mg/mL (198.4 mM)
Other Info	Exact Mass: 478.0577 Chemical Name: 4-[3-chloro-4-[[(2R)-3, 3, 3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]phenyl]sulfonyl-N, N-dimethylbenzamideSMILES Code: O=C(N(C)C)C1=CC=C(S(=O)(C2=CC=C(NC([C](C)(O)C(F)(F)F)=O)C(Cl)=C2)=O)C=C1
Synonyms	AZD-7545; AZD 7545; AZD7545; 4-[3-chloro-4-[[(2R)-3, 3, 3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]phenyl]sulfonyl-N, N-dimethylbenzamide

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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