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Description: PFK-015 (also known as PFK15) is a novel, potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM. In H522 lung adenocarcinoma and Jurkat cell lines, PFK15 exhibited cytotoxic effects with IC50 values of 2.42 and 0.72 uM in Jurkat and H522, respectively. Also, PFK15 reduced glucose uptake, intracellular ATP and F26BP, the substrate of PFKFB3. In Jurkat T cell leukemia cells, PFK15 (3 uM) increased the number of cells undergoing early apoptosis. PFK15 (3 and 20 uM) increased the number of cells undergoing late apoptosis in a dose dependent way.
References: Mol Cancer Ther. 2013 Aug; 12(8):1461-70.
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