pfk15

Item no.	V1937-250mg
Manufacturer	InvivoChem LLC
CASRN	4382-63-2
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1937CAS #:4382-63-2Purity >=98% Description: PFK-015 (also known as PFK15) is a novel, potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM. In H522 lung adenocarcinoma and Jurkat cell lines, PFK15 exhibited cytotoxic effects with IC50 values of 2.42 and 0.72 uM in Jurkat and H522, respectively. Also, PFK15 reduced glucose uptake, intracellular ATP and F26BP, the substrate of PFKFB3. In Jurkat T cell leukemia cells, PFK15 (3 uM) increased the number of cells undergoing early apoptosis. PFK15 (3 and 20 uM) increased the number of cells undergoing late apoptosis in a dose dependent way. References: Mol Cancer Ther. 2013 Aug; 12(8):1461-70.
Molecular Weight (MW)	260.29
Formula	C17H12N2O
CAS No.	4382-63-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 19 mg/mL (73 mM)
	Water: < 1 mg/mL
	Ethanol: 2 mg/mL (7.67mM)
Solubility (In vivo)	5% DMSO+45% PEG 300+1% Tween 80+ddH2O: 5mg/mL
Synonyms	PFK-015; PFK 015; PFK015.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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