tapi-1

Item no.	V1927-1mg
Manufacturer	InvivoChem LLC
CASRN	171235-71-5
Amount	1mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	171235-71-5
Available
Description	InvivoChem Cat #:V1927CAS #:171235-71-5 Purity >=98% Description: TAPI-1 is an ADAM17/TACE (TNF-alpha-converting enzyme) inhibitor, which blocks shedding of cytokine receptors. Specifically, it catalyzes the cleavage of full-length APP to the soluble N-terminal fragment (sAPPalpha). The release of sAPPalpha has been reported to be a receptor-coupled process increased by the stimulation of muscarinic receptors. In HEK293 cells, treatment of TAPI-1 resulted in an inhibition of increased sAPPalpha which was induced by the expressing of M3 subtype. The IC50 values of TAPI-1 in the inhibition of M3-increased sAPPalpha and constitutive release of sAPPalpha were 3.61 uM and 8.09 uM, respectively. References: J Immunol. 1995 Dec 1; 155(11):5198-205; Biochem J. 2001 Aug 1; 357(Pt 3):787-94; Life Sci. 2014 Mar 3; 97(2):137-44.
Molecular Weight (MW)	499.60
Formula	C26H37N5O5
CAS No.	171235-71-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 99 mg/mL (198.2 mM)
	Water: 60 mg/mL (120.1 mM)
	Ethanol: 99 mg/mL (198.2 mM)
Other info	Chemical Name: N-[(2S)-1-[[(2S)-1-(2-Aminoethylamino)-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide InChi Key: AWNBSWDIOCXWJW-OWHMDLSXSA-N InChi Code: InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9, 13, 16-17, 21-22, 36H, 10-12, 14-15, 27H2, 1-3H3, (H, 28, 33)(H, 29, 35)(H, 30, 34)(H, 31, 32)/t17-, 21?, 22-/m0/s1 SMILES Code: O=C(N[CH](CC1=CC=C2C=CC=CC2=C1)C(N[CH](C)C(NCCN)=O)=O)C(CC(C)C)CC(NO)=O
Synonyms	TAPI-1; TAPI 1; TAPI

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