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mefloquine-hcl

mefloquine-hcl

Item no.	V1908-2g
Manufacturer	InvivoChem LLC
CASRN	51773-92-3
Amount	2g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1908CAS #:51773-92-3 Purity >=98% Description: Mefloquine HCl (Mefloquin) is a blood schizonticide which inhibits hemozoin formation, and is used as a phospholipid-interacting antimalarial drug. Mefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria. Mefloquine can induces oxidative stress in vitro. Evidence indicates that reactive oxygen species (ROS) may be used as a therapeutic modality to kill cancer cell. Mefloquine inhibited KvLQT1/minK channel currents with an IC50 value of approximately 1 uM. Mefloquine slowed the activation rate of KvLQT1/minK and more block was evident at lower membrane potentials compared with higher ones. References: J Pharmacol Exp Ther. 2001 Oct; 299(1):290-6; Oncol Lett. 2013 May; 5(5):1541-1545. Related CAS #: 51773-92-3 (HCl) 53230-10-7 (free base) 64003-26-5 (mesylate)
Molecular Weight (MW)	414.77
Formula	C17H17ClF6N2O
CAS No.	51773-92-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 82 mg/mL (197.7 mM)
	Water: < 1 mg/mL
	Ethanol: 82 mg/mL (197.7 mM)
Solubility (In vivo)	Chemical Name: (S)-[2, 8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol; hydrochloride InChi Key: WESWYMRNZNDGBX-YLCXCWDSSA-N InChi Code: InChI=1S/C17H16F6N2O.ClH/c18-16(19, 20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21, 22)23)25-14(9)11; /h3-5, 8, 12, 15, 24, 26H, 1-2, 6-7H2; 1H/t12-, 15+; /m1./s1 SMILES Code: C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl
Synonyms	WR-177, 602; WR142, 490; WR177, 602; Ro215998001; Ro-215998001; Ro 215998001; Mefloquine Hydrochloride; Mephaquin; Mefloquine HCl; Loriam;

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Amount: 2g

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Delivery expected until 9/6/2024