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calcitriol

calcitriol

Item no.	V1857-5mg
Manufacturer	InvivoChem LLC
CASRN	32222-06-3
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	32222-06-3
Available
Description	InvivoChem Cat #:V1857CAS #:32222-06-3Purity >=98% Description: Calcitriol (RO215535, Topitriol; 1, 25(OH)2D3) is the metabolically/hormonally active form of vitamin D and a vitamin D receptor (VDR) agonist. Calcitriol is converted to metabolites more potent and rapidly acting than other forms of Vitamin D. Calcitriol has played an important role in mineral and skeletal homeostasis by regulating the differentiation, growth and the function of the cell immune system. In vitro studies, Calcitriol has been reported to dose-dependently inhibit the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in human peripheral blood cells (PBMC) stimulated by LPS. References: J Clin Invest. 1984 Oct; 74(4):1451-5; J Biol Chem. 1997 May 2; 272(18):11902-7.
Molecular Weight (MW)	416.64
Formula	C27H44O3
CAS No.	32222-06-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 83 mg/mL (199.2 mM)
	Water: < 1 mg/mL
	Ethanol: 83 mg/mL (199.2 mM)
Other info	Chemical Name: 1alpha, 25-Dihydroxyvitamin D3 InChi Key: GMRQFYUYWCNGIN-GSMZWGLTSA-N InChi Code: InChI=1S/C27H44O3/c1-18(8-6-14-26(3, 4)30)23-12-13-24-20(9-7-15-27(23, 24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11, 18, 22-25, 28-30H, 2, 6-9, 12-17H2, 1, 3-5H3/b20-10+, 21-11-/t18-, 22-, 23-, 24?, 25-, 27-/m1/s1 SMILES Code: O[CH](C/C1=C/C=C2C3CC[CH]([C]3(CCC/2)C)[CH](C)CCCC(C)(O)C)C[CH](O)C1=C
Synonyms	1, 25(OH)2D3; 1, 25(OH)2-D3; 1, 25(OH)2-VD3; 1, 25-Dihydroxyvitamin D3; RO215535, Topitriol; Rocaltrol; Calcijex; Topitriol; Silkis; Soltriol; 1alpha, 25-Dihydroxyvitamin D3; 1alpha, 25(OH)2D3

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Amount: 5mg

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