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nevirapine

nevirapine

Item no.	V1816-1g
Manufacturer	InvivoChem LLC
CASRN	129618-40-2
Amount	1g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1816CAS #:129618-40-2Purity >=98% Description: Nevirapine (also known as NSC 641530; BI-RG 587; NSC 641530; NVP) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV-1 infection and AIDS. It inhibits HIV-1 reverse transcriptase with a Ki of 270 uM. As with other antiretroviral drugs, HIV rapidly develops resistance if nevirapine is used alone, so recommended therapy consists of combinations of three or more antiretrovirals. Nevirapine in triple combination therapy has been shown to suppress viral load effectively when used as initial antiretroviral therapy. References: Drug Metab Dispos. 1999 Dec; 27(12):1488-95; Drug Metab Dispos. 1999 Dec; 27(12):1434-47.
Molecular Weight (MW)	266.3
Formula	C15H14N4O
CAS No.	129618-40-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 53 mg/mL (199.0 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 11-cyclopropyl-4-methyl-5, 11-dihydro-6H-dipyrido[3, 2-b:2', 3'-e][1, 4]diazepin-6-one InChi Key: NQDJXKOVJZTUJA-UHFFFAOYSA-N InChi Code: InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3, 6-8, 10H, 4-5H2, 1H3, (H, 18, 20) SMILES Code: O=C1C2=CC=CN=C2N(C3CC3)C4=NC=CC(C)=C4N1
Synonyms	NSC 641530; BI-RG-587; BIRG 0587; BIRG587; HSDB 7164; Nevirapine; NSC 641530; NVP; trade name: Viramune; Viramune XR.

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