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azd1981

azd1981

Item no.	V1806-25mg
Manufacturer	InvivoChem LLC
CASRN	802904-66-1
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1806CAS #:802904-66-1Purity >=98% Description: AZD1981 is a novel potent and selective CRTh2 (Chemoattractant receptor-homologous molecule expressed on TH2 cells; DP2-Prostaglandin D2 receptor 2, ) receptor antagonist with IC50 of 4 nM, it displayed > 1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has shown to inhibit eosinophil migration with a pIC50 value of 7.6+/-0.1. It could block chemotaxis of DP2+ T-cell lines with a pIC50 value of 7.5+/-0.1. AZD1981 inhibited PGD2 by binding to mouse, rat, rabbit, dog, guinea pig and human DP2. AZD1981 is currently being developed for the treatment of asthma. References: Br J Pharmacol. 2013 Apr; 168(7):1626-38; Bioorg Med Chem Lett. 2011 Nov 1; 21(21):6288-92.
Molecular Weight (MW)	388.87
Formula	C19H17ClN2O3S
CAS No.	802904-66-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 11 mg/mL (28.3 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
SMILES	O=C(O)CN1C(C)=C(SC2=CC=C(Cl)C=C2)C3=C1C=CC=C3NC(C)=O
Synonyms	AZD1981; AZD-1981; AZD 1981

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