lcz696

Item no.	V1778-250mg
Manufacturer	InvivoChem LLC
CASRN	936623-90-4
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1778CAS #:936623-90-4Purity >=98% Description: LCZ696 (also known as Sacubitril mixture with Valsartan), chemically conposed of valsartan and sacubitril in 1:1 molar ratio, is a novel, potent, orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. In Sprague-Dawley rats, oral administration of LCZ696 led to a dose-dependent rise in immunoreactivity of atrial natriuretic peptide resulting from neprilysin inhibition. In hypertensive double transgenic rats, LCZ696 caused a dose-dependent and sustained reduction in mean arterial pressure. References: J Clin Pharmacol. 2010 Apr; 50(4):401-14; Circ Heart Fail. 2015 Jan; 8(1):71-8. Related CAS#: 137862-53-4 (Valsartan); 149690-05-1 (Valsartan sodium)
Molecular Weight (MW)	915.98
Formula	C24H29N5O3.C24H29NO5.5/2H2O.3Na
CAS No.	936623-90-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 30 mg/mL warmed (32.8 mM)
	Water: 100 mg/mL (109.2 mM)
	Ethanol: 9 mg/mL (9.8 mM)
Other info	Chemical Name: sodium (S)-5-(4'-((N-(1-carboxylato-2-methylpropyl)pentanamido)methyl)-[1, 1'-biphenyl]-2-yl)tetrazol-1-ide 4-(((2S, 4R)-1-([1, 1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate hydrate InChi Key: UOLUPHRXIRFONO-JOYYXRJNSA-K InChi Code: InChI=1S/C24H29N5O3.C24H29NO5.3Na.H2O/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23; 1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19; ; ; ; /h6-9, 11-14, 16, 22H, 4-5, 10, 15H2, 1-3H3, (H2, 25, 26, 27, 28, 31, 32); 4-12, 17, 21H, 3, 13-16H2, 1-2H3, (H, 25, 26)(H, 27, 28); ; ; ; 1H2/q; ; 3*+1; /p-3/t22-; 17-, 21+; ; ; ; /m01..../s1 SMILES Code: CC(C)[CH](C([O-])=O)N(C(CCCC)=O)CC1=CC=C(C2=CC=CC=C2C3=NN=N[N-]3)C=C1.O=C(OCC)[CH](C)C[CH](NC(CCC([O-])=O)=O)CC4=CC=C(C5=CC=CC=C5)C=C4.[Na+].[Na+].[Na+].O
Synonyms	LCZ696; LCZ-696; LCZ 696. valsartan / sacubitril (1:1). trade name: Entresto.

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Amount: 250mg

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