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Description: Divalproex Sodium, conposed of two compounds of sodium valproate and valproic acid in a 1:1 molar ratio in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy. Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1.
References: Cancer Lett. 2015 Jan 28; 356(2 Pt B):791-9.
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