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Description: TVB-3166 is a novel, potent, orally bioavailable, reversible and selective inhibitor of fatty acid synthase (FASN) inhibitor (IC50s of 42 nM and 81 nM in biochemical and cellular assay, respectively. ), it acts by inducing apoptosis, inhibiting anchorage-independent cell growth under lipid-rich conditions, and inhibiting in-vivo xenograft tumor growth.
References: Inhibitionof de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosisin Tumor Cells by Remodeling Cell Membranes, Inhibiting SignalingPathways, and Reprogramming Gene Expression. EBioMedicine. 2015 Jul2; 2(8):808-24.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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