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kpt-276

kpt-276

Item no.	V1683-500mg
Manufacturer	InvivoChem LLC
CASRN	1421919-75-6
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1683CAS #:1421919-75-6Purity >=98% Description: This product has been discontinued. KPT-276 is a potent, orally bioavailable, and selective CRM1 inhibitor. KPT-276 rreversibly binds to CRM1 and blocks CRM1-mediated nuclear export. In human multiple myeloma (MM) cell lines (HMCLs), KPT-276 irreversibly and specifically inhibited the nuclear export of XPO1, which encoded CRM1 and significantly reduced the viability of HMCLs. In bone marrow cells isolated from MM patients, KPT-276 induced apoptosis. Also, KPT-276 downregulated the expression of c-MYC, CDC25A and BRD4, which caused G1/S phase arrest. References: Blood. 2012 Aug 30; 120(9):1765-73; Exp Hematol. 2013 Jan; 41(1):67-78.e4.
Molecular Weight (MW)	426.26
Formula	C16H10F8N4O
CAS No.	1421919-75-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 20 mg/mL (46.9 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 5 mg/mL
Synonyms	KPT-276; KPT 276; KPT276

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500mg

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Delivery expected until 9/6/2024

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