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epothilone-a

epothilone-a

Item no.	V1619-250mg
Manufacturer	InvivoChem LLC
CASRN	152044-53-6
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1619CAS #:152044-53-6Purity >=98% Description: Epothilone A (also known as Epo A), similar to paclitaxel, is also a naturally occurring microtubule-stabilizing macrolide agent (also called mitotic inhibitor or tubulin inhibitor). It was first isolated from the myxobacterium Sorangium cellulosum. The IC50 value of Epothilone A in HCT-116 cell line is 4.4 nM. It has been found that the SKOV-3 human ovarian cancer cells were susceptible to Epothilone A with IC50 value of 20.4 +/- 1.4 nM. The antiproliferative capacity of Epothilone A in SKOV-3 cell line (measured as IC50 after 72 h continuous treatment) was six times greater than that of PTX’s. Besides, Epothilone A induced time coursedependent apoptosis and necrosis. References: Org Lett. 2001 Aug 23; 3(17):2693-6; Cancer Res. 1995 Jun 1; 55(11):2325-33.
Molecular Weight (MW)	493.66
Formula	C26H39NO6S
CAS No.	152044-53-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 99 mg/mL (200.5 mM)
	Water: < 1 mg/mL
	Ethanol: 99 mg/mL (200.5 mM)
SMILES	O=C(C(C)(C)[CH](O)C1)[CH](C)[CH](O)[CH](C)CCC[C]2([H])O[C]2([H])C[CH](/C(C)=C/C3=CSC(C)=N3)OC1=O
Synonyms	Epothilone-A; EpoA; (1R, 5S, 6S, 7R, 10S, 14S, 16S)-6, 10-Dihydroxy-5, 7, 9, 9-tetramethyl-14-[(E)-1-(2-methyl-1, 3-thiazol-4-yl)prop-1-en-2-yl]-13, 17-dioxabicyclo[14.1.0]heptadecane-8, 12-dione

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Amount: 250mg

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Delivery expected until 10/4/2024

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