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bvt-2733

bvt-2733

Item no.	V16006-50mg
Manufacturer	InvivoChem LLC
CASRN	376640-41-4
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V16006CAS #:376640-41-4Purity >=98% Description: BVT-2733 is a selective 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, which attenuates obesity and inflammation in diet-induced obese mice. BVT-2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. BVT-2733 exhibits an anti-inflammatory effect on CIA. This protective effect is, at least partly, mediated by inhibition of the NF-kappaB and NLRP1 inflammasome signaling pathways. 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) plays an important role in inflammation. 11beta-HSD1 inhibition may represent a potential therapeutic target for RA patients. References: Zhang L, Dong Y, Zou F, Wu M, Fan C, Ding Y. 11beta-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov; 17(3):489-94. doi: 10.1016/j.intimp.2013.07.015. Epub 2013 Aug 11. PubMed PMID: 23938253.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50mg

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